Title, Evolution by gene duplication. Author, Susumu Ohno. Edition, illustrated. Publisher, Springer-Verlag, Original from, the University of Michigan. Title, Evolution by Gene Duplication. Author, Susumu Ohno. Edition, illustrated. Publisher, Allen & Unwin, ISBN, , The genome of S. cerevisiae is characterized by a high genetic redundancy which can largely be attributed to a whole genome duplication event (Ohno, ;.
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Not a MyNAP member yet? Register for a free account to start saving and receiving special member only perks. The second of five children, he was the son of the minister of education of the Japanese Viceroyship of Korea. He was born at a time when Japan was in many ways isolated from Western thought with its chief scientific links firmly established with Germany, and he was schooled in the years when a bitter war was fought between Japan and the United States and its Western allies.
His maternal grandfather had been a justice of the Supreme Court of Korea and his paternal grandfather had been a scholar of Chinese language and history. As a high government official his father had traveled extensively, and Susumu lived in Korea and Japan during his childhood. His father nurtured ideas that were unusually liberal for someone in his position.
He believed, for example, that people of all races were equal, an idea that impressed Susumu and one that he carried with him for his whole life. He was denied entry into the government public school because, he said, of his liberal propensities.
Instead, he was sent by his family to one of the best private schools. In addition, he was taught by tutors to learn Chinese language and Chinese history. Of his siblings Susumu was the only one to leave Japan; all of his brothers and his sister lived their entire lives on the Japanese islands.
His love of animals, particularly of horses, proved to be one of the most pervasive influences in his life. His father was entitled to maintain both an automobile and a horse on his property, and he normally traveled to his office on horseback. He wanted to attend veterinary school. At first his father was opposed to this choice, suggesting a career in medicine instead. Nevertheless, veterinary school it was, and Ohno received a D.
Indeed, it was owning and training horses that were to be a lifetime avocation for both Susumu and Midori. Ohno selected the Hokkaido University Faculty of Sciences for his graduate studies, because a professor there, Sajiro Makino, was well known for his study of chromosomes, a topic that had begun to interest Ohno.
Evolution by gene duplication
Evolutlon doctoral dissertation concerned the role of plasma cells in the production of antibody, and in Ohno was awarded his Ph. His graduate work in the area of immunology brought him in contact with Keiji Aoyama, and it was through this.
Although their romance flourished in a society in which, at the time, arranged marriages were common, they did not marry in Japan.
Ohno saw that the future of science lay in the United States, and before they could be married, duplidation had obtained an appointment at the University of California, Los Angeles, in the department of Charles Carpenter. Although he was of Japanese origin, Kinosita had traveled extensively abroad and had worked in Germany and England.
There he had discovered that butter yellow was a carcinogen, and largely because of this discovery he had become internationally known. He asked young Ohno to join him in establishing this new research program.
Apparently it was an exciting challenge for both of them, and Ohno moved to the institution where he was to spend his entire highly productive career. It was very difficult for a Japanese woman to obtain a visa to enter the United States in the early s, so Midori stayed behind in Japan and married Susumu by proxy while she was in Japan and he in the United States.
In she was able to join him. Their marriage produced three susumh. The oldest, a son named Azusa, was born in and is now a film director in southern California. The second child was a daughter, Yukali, who studied philosophy and now lives ohni her husband in Hawaii.
The youngest son lives in Sisumu Vegas, where he works as a croupier. When beginning his work at the City of. Hope Medical Center he skillfully devised cinematographic techniques for the study of living bone marrow. While these studies hardly foretold the profound insights that Ohno would have into biologic mechanisms, they established him as a highly skilled experimentalist.
With these skills he moved into the second phase of his career as a scientist, the study of oho. Here his abilities as an experimentalist complemented his deep biologic insights and led him to a discovery that was to influence our understanding of genetic mechanisms. He recognized that the chromatin body that was found in female cells was not, as had been previously thought, the two X chromosomes lying in apposition but rather that one X chromosome was heterochromatic.
This discovery, which Ohno later singled out as being possibly the most important of his career, served to focus his attention upon chromosomal function, gnee with respect susumuu sex determination, and eevolution was in this area that he made additional highly original contributions.
Since it was known that in insects heterochromatin was genetically inactive, this suggested independently to a number evolutiion scientists that one of the two mammalian female chromosomes might be genetically inactive. In studying the phylogenetic derivation of the X chromosomes, he recognized that they must have developed from a pair of autosomes, one of which underwent specialized development. In mammals this ultimately led to the nearly functionless Y chromosome. For a time he became fascinated with the H-Y antigen but began to realize that the antisera that were available were of such poor quality that the results were not reliable.
He later acknowledged that dpulication had been, ecolution a short time, misled by the results obtained. In studying the chromosomes of mammals he noted that while there was great diversity in the number of chromo. At a time that many were doing much less profound work, using highly sophisticated techniques, Ohno carefully made chromosome spreads, photographed them, and cut the dupllcation from photographic paper.
He then weighed the cutout chromosomes showing in this way that whether there were 17 pairs of chromosomes as in the creeping vole, Microtus oregoni, or 84 pairs as in the black rhinoceros, the amount of susmu material was the same.
But he found that this was not the case in organisms lower on the phylogenetic tree. Here it seemed to duplicaiton that there had been successive doublings of the amount of chromosomal material. Ohno undertook to write three monographs in which he evolutoon his innovative ideas about chromosomes and sex determination. Although his ample bibliography is replete with multiauthored papers in leading scholarly journals, it is in these monographs that he was able to most fully explore his innovative ideas about biology.
The preface of the first of these books reads as follows:. On the premise that each field of natural science has become too complex to be comprehended by a single man, it is more fashionable today to organize a committee of specialized scientists to write one book. While a book, written by a committee tends to present an objective appraisal of current knowledges, it suffers from disunity of thoughts. It is my sincere desire that this book will manifest more merits than shortcomings in having been written by one author.
This monograph dealt with the evolution of the X and the Y chromosomes in mammals and the Z and Susuju chromosomes in avian and ophidian species. It discussed in detail evolutio X-inactivation hypothesis to which Ohno contributed so much and considered various mechanisms of dosage compensation. The second monograph on gene duplication was far ahead of its time.
In the preface he wrote:. Had evolution been entirely dependent upon natural selection, from a bacterium only numerous forms of bacteria would have emerged.
Evplution creation of metazoans, vertebrates, and finally mammals from unicellular organisms would have been quite impossible, for such big leaps in evolution required the creation of new gene loci with previously nonexistent function.
Only the cistron that became redundant was able to escape from the relentless pressure of natural selection. By escaping, it accumulated formerly forbidden mutations to emerge as a new gene locus.
Thus, he recognized that this DNA could serve as susummu powerful means by which new genes or new functions of old genes could be created.
Susumo Ohno | Biographical Memoirs: V | The National Academies Press
This concept evolutioj been expressed earlier by Haldane, but the explosion in modern biology and molecular genetics made it possible to assess for the first time the important role that gene duplication played in evolution. The third volume dealt in greater detail with sex determination.
Ohno was fascinated by the testicular feminization syndrome, in which XY persons do not only develop into phenotypic females but into females who are particularly beautiful. A mutation on the X chromosome that causes resistance to the effect of male hormones is responsible for this disorder.
In the evoltion s Ohno became interested in the evolution of DNA sequences.
He realized that the decamers that might be formed in the primordial soup through known chemical reactions would not be sufficient to contain the. Accordingly, he proposed that the primordial oligonucleotides were repeating pentamers that hybridized with one another, forming templates tene elongation.
The result would be a repeating sequence, but because the repeating unit was five nucleotides long, there would be a frameshift in a triplet code, resulting in the formation of longer amino acid sequences, which however, evilution also be repeating in nature.
In searching the rapidly increasing number of sequences that were becoming available, Ohno saw many recurring motifs and thought it would be interesting to assign notes to nucleotides, converting the sequences into musical passages. This made it possible to appreciate the repeating nature of motifs in the DNA sequence in a much more pleasant fashion than scanning the monotonous repeating letters of the sequences. This approach had a great deal of popular appeal and Susumu and Midori, who was musically proficient as a singer, were often called upon to perform some of their transcriptions of sequences into music.
He has thought at least half of the thoughts that form the basis of the work being carried out all over the world in respect to genetic analysis. In particular, the notion that every new gene arises from an already existing gene has revolutionized research. Honorary degrees were conferred upon him by the University of Pennsylvania in and by the Tokyo University of Agriculture and Technology in In the last year of his life he made a final journey to Japan with Midori.
On that occasion Ohno was accorded the rare privilege of a personal meeting with the emperor of Japan, and upon his passing the emperor and empress sent their personal condolences to Mrs. Novak, director of professional education ohnk scientific reports at the City of Hope National Shsumu Center, was a great aid in writing this biographical memoir, and the author appreciates this valuable resource being made available.
A photographic representation of mitosis and meiosis in the male of Rattus norvegicus. On the end-to-end association of the X and Y chromosomes of Mus musculus. D Kaplan and R. The centromeric and nucleolus-associated heterochromatin of Rattus norvegicus.
Susumu Ohno – Wikipedia
Formation of the sex chromatin by a single X-chromosome in liver cells of Rattus norvegicus. Allocycly of the X-chromosome in tumors and normal tissues. On isopycnotic behavior of the XX-bivalent in oocytes of Rattus norvegicus. The single-X nature of sex chromatin in man.
Chromosomal constitution in glucosephosphate-dehydrogenase deficiency. X-chromosome behavior in germ and somatic cells of Rattus norvegicus. X-autosome ratio and the behavior pattern of individual X-chromosomes in placental mammals. Sex-linkage of GPD in the horse and donkey.
Sex-linkage of erythrocyte glucosephosphate dehydrogenase in two species of wild hares. Sex-linkage of the glucosephosphate dehydrogenase gene in Equidae. Hexosephosphate dehydrogenase found in human liver. Genetically directed preferential X-activation seen in mice. The all pervasive principle of repetitious recurrence governs not only coding sequence construction but also human endeavor in musical composition.