Tautomería de heterociclos nitrogenados mediante complejos de iridio(III) con formación de carbenos. N-heterocíclicos. Ana Rita Guerreiro De Brito Petronilho. – Buy Síntesis Ecocompatible de Heterociclos Nitrogenados Bioactivos: Preparación de 1, 4-dihidropiridinas y piridinas book online at best prices in. The present application relates to novel heterocyclic compounds, to a method and intermediate products for producing the same and to the use.
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Compounds of the benzylamine class are potent inhibitors of phenylethanolamine N-methyltransferase.
In fact, 1,2,3-triazoles show several applications in many areas especially as medicines against many diseases like cancer, AIDS, Parkinson and Alzheimer. C 13 H 16 O 4 requires C, The low yields of the cyclic bases were accounted for by the peculiar stereochemical configuration of the 4,5-ethylene-3,4-dihydroisoquinoline. A solution of the ester 12 8 1g, 3. C The solution was stirred at reflux for 3 h heterociflos then concentrated in vacuo.
The mixture was filtered through Celite and the filtrate extracted with CHCl 3 3×50 ml.
Síntese de precursores de heterociclos e sistemas cíclicos nitrogenados
An attempt was made to synthesize conformationally restricted nitrogen heterocycles by means of the Bischler-Napieralski reaction and Tsuda modification. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Acta, CA A mixture of 14 mg, 2. N -Acetyl- 5,6-dimethoxyindanyl methylamine 18 To a solution of 5,6-dimethoxyindanyl methylamine 8 0.
Observed results prompted us to speculate on the nature of the effects which may be controlling such cyclization processes. In the modification proposed by Tsuda, 9 the reaction seems to proceed by initial activation of the isocyanate to an activated species sp 2 see Scheme 2.
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Nova28 New York,p. Acta79 This was converted into isoquinolone 9 in good yield. After one hour, the mixture was extracted with benzene 3×10 ml.
Japan, 47 Perkin I, C 14 H 19 NO 3 requires C, Mendoza, J; Torres, T. Bischler-Napieralsky, Tsuda, nitrogen heterocycles, cyclizationisoquinolones, isoquinolines. Infrared spectra were performed on a Jasco A spectrometer as mulls or heterociflos. The preparation of 18 was accomplished from 12 using a procedure previously described by us. Nevertheless, there is no article that gives an objective overview of the synthetic methods for obtaining these kinds of azoheterocycles.
The excess of the reactive was removed in vacuo and the residue dissolved in CH 2 Cl 2 10 ml. N -Benzoyl 5,6-Dimethoxyindanyl ethylamine 17 To a solution of the amine 15 mg, 2.
Química verde: un nuevo enfoque ambiental para la síntesis de isoquinolinas y sus derivados
C 13 H 17 NO 3 requires C, Quite likely, this peculiar stereochemical configuration could be obtained more easily from structure 9 rather than from 5. Full conformational restriction of the benzylamine side chain in analogues 1 leads to a loss in inhibitory potency.
This result is comparable to the one obtained by Heterocixlos and Lions 2 using strong cyclodehydrating agents on amides in reactions mediated by the nitrilium ion. The mixture was stirred at reflux for 2h, then cooled, diluted with water and extracted with CHCl 3 3×30 ml. The 1,2,3-triazole, known since the end of 19 th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds.
Finally, acetyl and benzoyl derivatives 16 and 17 were nitrovenados.